Chemical and biological effects of some mixtures of plant oils and Thymus vulgaris on liver diseases

Ismael, Samah; Abdelrahman, Abour; Sultan, Eman; Omran, Shaimaa M

doi:10.21608/ajbs.2020.126867

Chemical and biological effects of some mixtures of plant oils and Thymus vulgaris on liver diseases

Document Type : Original Article

Authors

¹ Home Economic Dept., Faculty of Specific Education, Ain Shams Univ., Cairo, Egypt

² Endocrinology and Metabolism Department, National Nutrition Institute, Egypt

10.21608/ajbs.2020.126867

Abstract

Liver is the vital organ with a wide range of functions that can influence other body organs. Dietary components are essential for the healthy or diseased liver. Selected food plants can provide nutritional and medicinal support for liver diseases. Herbal and oil medicinal products are increasingly being used and many of them have shown promising potential for the treatment of liver diseases. The aim of this study is to investigate the protective role of thyme, olive oil and flaxseed oil on carbon tetrachloride CCl₄ induced changes in liver enzymes of albino rats.
Sixty adult male Albino rats weighing about 130±5 g were taken and divided into twelve groups, each with five rats. The first group is the control (-) and fed on normal diet for 10 weeks. The second group received subcutaneous injection with CCL₄ in paraffin oil (50% v/v 2 ml/kg) twice per week for 2 weeks to induce chronic damage in the liver tissue and fed on normal diet (control +). Another experimental groups (n = 5/group) were fed a Commercial diet with different doses from thyme, flaxseed oil and olive oil for 10 weeks.
There were a significant increase in the activities of serum ALT and AST in rats of the positive control group (+) as compared to negative control group (-) (P ≤ 0.05).While the protected groups with high doses of thyme (4,6,8,10,12) and olive oil and flaxseed oil (3,5,7,9 ,11 ) recorded a significant decreased serum AST and ALT enzyme compared to the low doses groups.
Recommendations and Conclusion: High doses of thyme, olive oil, and flaxseed oil could ameliorate carbon tetrachloride (CCl4)-induced liver injury in rats, which. Suggesting that diet rich in flaxseed oil, olive oil and thyme might be a promising approach for the prevention of liver diseases.

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