Comparative study on the effectiveness of gum arabic Acacia senegal and Moringa oleifera extracts on prevention of peptic ulcer in the experimental rats

Document Type : Original Article

Authors

1 Prof.Of Nutrition and food science Ain shams university Faculty of specific education Department of home economics

2 Assist. Prof.Of Nutrition and food science Ain shams university Faculty of specific education

3 Home economic (Nutrition &food science)Ain shams university, cairo, egypt

Abstract

Peptic ulcer is one of the world’s major gastrointestinal disorders and affecting 10% of the world population. An estimated 15000 deaths occur each year as a consequence of peptic ulcer. The cost of treatment for peptic ulcers is expensive and has side effects. So, it is necessary to conduct research to develop new therapeutic agents for the treatment of stomach ulcers. It is known that medicinal plants are important sources of biologically active molecules with the genetic ability of anti-ulcer. This study aims to evaluate the effectiveness  of using gum arabic Acacia senegal and Moringa oleifera extracts on treatment of peptic ulcer in the experimental rats. Fifty rats were divided into 8 groups (6/each group). One group feeds the basic diet only (positive control group, G+). The remaining 44 rats were infected by aspirin solution to induce peptic ulcer in their stomach. One group of these rats   feeds the basic diet only (negative control group, G-). Three groups G1, G2 and G3 feed on the basic diet + gum arabic extract (500, 1000 and 1500 mg/kg of rat weight). The other groups G4, G5, G6 feed the basic diet+ Moringa oleifera extract (800, 1000 and 1200 mg/kg of rat weight). At the end of the experiment (6 weeks), rats were fasted for 12 hours before slaughtering, blood samples were collected to obtain the serum, the stomach was separated for examination and gastric juice was collected to determine the (PH).
The results indicated that rats in groups G6 and G3 had the highest increase in number of their WBC and in their HP as compared to (G+).
Histological study revealed the absence of histopathological changes in G3 and G6 , while other groups showed mucosal vascular congestion and submucosal edema with inflammatory cell infiltration.

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