The roles of Arabic Gum and Corn silk extracts to avoid hepato-nephro toxicity of Gentamicin in rats

Document Type : Original Article

Authors

1 Home Economic Dept., Faculty of Specific Education, Ain Shams Univ.,Egypt

2 Food Science Dept.,Fac. of Agric., Ain Shams Univ., Egypt

Abstract

ABSTRACT
            The effects of different concentration of Arabic Gum (AG) and corn silk (CS) extracts against hepato-nephro toxicity which induced by gentamicin (GM) in experimental rats were investigated. 25 bioactive constituents in the extract of CS were investigated by GC-MS analysis;Phytol (3.325 μg/g) was the major constituent with antioxidant properties and can reduce free-radical generation in an in-vitro experimental system.GM at a dose 80 mg/kg, intraperitoneal (ip) for 8 sequential days was used to induce nephrotoxicity, manifested biochemically by a significant increase in serum creatinine, blood urea and uric acid. In addition, liver enzymes, Total Bilirubinincreased and total protein decreased. All extracts showed a significant effect in improving kidney function, liver enzymes, total protein and Bilirubin. The histopathological investigation of liver and kidney in rats injected with GM showed that, the best improvement in liver enzymeswere obtained by using 20% Arabic Gum Extract (AGE) +5% Corn Silk Extract (CSE) and 10% AGE,while using 10% CSE, 10% AGE and 20% AGE improved kidney function compared with control (+) group.

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