Association between "TCF7L2 (rs7903146)" & "KCNQ1 (rs2237895 & rs2237892)" genetic variants & type 2 diabetes in Egyptian patients.

Document Type : Original Article

Author

Molecular Biology Department, Genetic Engineering and Biotechnology Institute, University of Sadat City, Sadat City, Egypt

Abstract

Diabetes mellitus "simply diabetes "is a serious case in which "blood glucose levels "rise because their bodies are unable to produce any or enough insulin, or because they are unable to use the insulin produced efficiently. Is the most prevalent type of diabetes, affecting nearly 90% of all diabetes worldwide. If you have T2DM, your body does not use insulin properly. This is known as insulin resistance. To compensate, the pancreas initially produces extra insulin. Over time, your pancreas is unable to keep up and produces insufficient insulin to maintain normal blood glucose levels. In this study, we investigate whether KCNQ1 and TCF7L2 SNPs were diabetic patient’s risk factors by conducting a thorough case control. KCNQ1 (rs2237892) and (rs2237895) and TCF7L2 (rs7903146) PCR-RFLP analysis was used to genotype 66 T2D patients and 34 healthy controls. In KCNQ1 (rs2237892) and TCF7L2 (rs7903146) for diabetic patients has a relatively high risk for diabetes, KCNQ1 (rs2237895) showed no statistically significant between the diabetic patients & the healthy group. Conclusion the TCF7L2 rs7903146 and KCNQ1 rs2237892 are the most unambiguous genetic factors influencing type 2 diabetes in Egyptians.

Keywords

African Journal of Biological Sciences

Articles in Press, Accepted Manuscript
Available Online from 18 August 2022

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