Potential protective role of Melilotus officinalis against Cisplatin –induced cardiac and pulmonary toxicities in rats

Ismaieel, Ahmed R.; Fadl, Hassan Hamadnaallah; Abu El-Hassan, Gawhara

doi:10.21608/ajbs.2021.80376.1020

Potential protective role of Melilotus officinalis against Cisplatin –induced cardiac and pulmonary toxicities in rats

Document Type : Original Article

Authors

¹ Department of Entomology, Faculty of Science, Ain Shams University, Abbassia- Cairo, Egypt.

² Entomology Department, Faculty of Science, Ain Shams University

³ Entomology department, faculty of science, Ain Shams University

10.21608/ajbs.2021.80376.1020

Abstract

Cisplatin (Cis) is a chemotherapeutic drug that is currently used to treat a variety of cancers. However, intrinsic cardiac and pulmonary toxicities, as well as other adverse effects, limit its practical application. Because Melilotus officinalis (MO) contains anti-oxidant and anti-inflammatory capabilities, the current study was conducted to look into Melilotus officinalis' preventive impact against cisplatin-induced heart and lung damage. Thirty rats were unsystematically divided into six groups (A–F) of 5 rats each: Group A which served as control received water; Group B was intraperitoneally (i.p) injected 5 mg/kg of Cis intraperitoneally once in every 2 days for a total of 8 days; Groups C and D were given 100 and 200 mg of MO via oral administration, respectively, for 7 weeks and then exposed to i.p administration of 5 mg/kg b. wt cisplatin on the 7st week; Groups E and F received 5 mg/kg b. wt of cisplatin intraperitoneally and then received 100 and 200 mg kg b.wt of MO for 7 weeks orally. Cisplatin administration resulted in elevated levels of LDH, CK, MDA, and TNF-and significant decreases in SOD levels in the heart tissues, as well as a significant decrease in lung GSH and Caspase-3 activity. In contrast, MDA levels increased considerably in the Cis-treated group compared to the control group. In groups C and D rats, pretreatment with MO improved all of the prior measures in conjunction with cisplatin. MO also showed improvements in histological structures.

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