Overexpression of the Chemokine Receptor CCR7 In Patients with Hepatocellular Carcinoma: Correlation with Disseminated Circulating Tumor Cells.

Document Type : Original Article

Author

cairo cairo

Abstract

Disseminated circulating tumor cells (CTCs) are cancer cells that have detached from the primary tumor and survived in the circulation, thus enable the spread of cancer from its site of origin. The chemokine receptor 7 (CCR7) has been linked to tumor dissemination and poor prognosis in solid tumors. However, its relationships with CTCs in liver cancer still not clear. This study aimed to identify the relationship between CCR7 and CTCs in hepatocellular carcinoma patients, and to assess their predictive values as noninvasive markers. Seventy-one HCC patients and 20 normal individuals were included. CTCs were detected in the peripheral blood by flow cytometry defined as CD45¯CK19+CD90+ cells. Expression of CCR7 was assessed by real time PCR. Clinical and routine laboratory investigations included tumor size, number of tumors detected by ultrasound, alpha fetoprotein (AFP), CBC, PT, INR, ALT, AST, bilirubin, albumin, and creatinine were also analyzed. Results: HCC patients were classified according to their Childs-Pugh score system (CPSS) into 2 subgroups A5 (N=51) and A6 (n=20). Results revealed that CCR7 mRNA increased significantly in HCC patients and its elevation was correlated with CTCs count.

Keywords

African Journal of Biological Sciences

Articles in Press, Accepted Manuscript
Available Online from 05 November 2022

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