Favipiravir Determination by the Enhancement of the Emission of Sm3+ Optical Sensor

Document Type : Original Article

Authors

1 abbassia

2 chemistry department, faculty of science, ain shams university

Abstract

Favipiravir discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza. The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes The efficiency of excited-state interaction between Sm3+ and the industrial product Favipiravir (Fav) has been studied in different solvents and various pH values. High luminescence Intensity peak at 645 nm of Samarium complex in DMF was obtained without any change in solvent pH value. The photophysical properties of the Emissive Sm3+ Complex have been elucidated, the Samarium was used as optical sensor for the assessment of Fav in the pharmaceutical tablets λex=370 nm with a concentration range (16-600) µg/mL of Fav, correlation coefficient of 0.97 and detection limit of 8 µg/mL. In this work, Fav concentration was determined by the complexation between Fav as a ligand and the Sm3+ Ion and the possibility of the enhancement of the Sm3+ luminescence sensitized by Fav was established and investigated. The absorption and emission spectra of Fav and (Fav-Sm3+) complex were measured in DMF without any change in pH value. This method is simple, accurate and can successfully be applied to the determination of Fav in pharmaceutical preparation samples with remarkably satisfactory results.

Keywords

African Journal of Biological Sciences

Articles in Press, Accepted Manuscript
Available Online from 20 February 2023

Files

Share

How to cite

Statistics