Effect of Saussurea costus on propylthiouracil induced hypothyroidism in rats

Document Type : Original Article

Authors

1 Nutrition and Food Science, Home Economic Dept., Faculty of Specific Education, Ain Shams University, 11566, Egypt

2 Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University

Abstract

The present aims to evaluate the effect of Saussurea costuson on Propylthiouracil (PTU)-induced hypothyroidism in rats. The chemical composition, phenolic compounds and antioxidant activity in this plant were evaluated. Thirty male albino rats weighing about 170±10 g was divided into five groups; negative control group, positive control group, and three treated groups with S. costus (100, 200 and 400 mg/kg bodyweight, respectively. The thyroid gland activity was evaluated utilizing biochemical and histopathological methods. The results indicated that the positive control group showed a significant increase in kidney and liver function biomarkers and a significant decrease in FT3, FT4, and TSH hormones. On the other hand, rats with induced hypothyroidism showed significant reduction in their body weight gain with different doses of S. costus. Also, the treated rats showed normal biochemical and hormonal levels, as well as normal histological results like the control group. This indicated that S. costus exhibits a promising effect in ameliorating PUT-induced hypothyroidism by regulating hormonal levels and restoring tissue damage, making it a potential natural candidate for future therapeutic studies.  

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