Effects of licorice root powder on lipid peroxidation and antioxidant status in arthritis-induced rats

Document Type : Original Article

Authors

1 Nutrition and Food Science, Home Economic Dept., Faculty of Specific Education, Ain Shams University, Egypt

2 Nutrition and Food Science, Home Economic Dept., Faculty of Specific Education, Ain Shams University, Egypt.

3 Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by chronic inflammation that leads to progressive joint damage and disability. The pathogenesis of RA involves complex inflammatory cascades and is closely associated with oxidative stress and lipid peroxidation. The present study was performed to evaluate the effect of licorice root powder on lipid peroxidation and antioxidant status in arthritis-induced rats. Thirty adults female wistar rats (210±5g) were weighted and randomly allocated into two main groups. Group (1) control (ve-) (6 rats) received standard diet only, while the second group (24 rats) arthritis was induced through an intradermal injection of Complete Freund’s Adjuvant (CFA) (0.1 mL) at the right hind footpad on day one. Then rats were divided into five subgroups, Group (II), arthritic group (ve+) received standard diet only. Group (III) treated with 5 % licorice / diet daily. Group (IV) treated with 10 % licorice / diet daily. Group (V) treated with 15 % licorice / diet daily. The results showed significantly observed (p ≤ 0.05) in the serum levels of biochemical parameters and significantly reduced lipid peroxidation in all treated groups.
 

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