Prevalence of multidrug resistance in the Egyptian methicillin-resistant Staphylococcus aureus isolates

Document Type : Original Article


1 National Organization for Drug Control and Research, Giza, Egypt

2 Department of Microbiology, Faculty Science, Ain Shams Univ., Cairo, Egyp

3 Department of Biochemistry, Faculty of Veterinary Medicine, Cairo Univ., Giza, Egypt

4 Department of Microbiology, Faculty Science, Ain Shams Univ., Cairo, Egypt


Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major health hazards and became of greater public health concern. This work aimed to shed substantial light on prevalence of MRSA in different clinical isolates and their resistance to different antibiotics. Among 258 Staphylococcus aureus isolates recovered from different clinical sources (urine, pus, throat swab, blood, seminal fluid, prostatic fluid, sputum swab, ascetic fluid, skin swab, nipple discharge and urinary catheter). 70 isolates were identified as MRSA. The highest percentage of MRSA was recorded from pus samples (57.1%) followed by urine (30%). Antimicrobial susceptibility test using 14 antibiotics showed that all MRSA were resistant to amoxicillin and cefuroxime, while only 50% were sensitive to vancomycin. High minimum inhibitory concentration of oxacillin (256 µg/ml) was detected in 12.9% of MRSA isolates.